Uniform Data Set version 4
UDSv4 - Template

United States

Reference ID

USDv4

Producer(s)

National Alzheimer’s Coordinating Center (NACC) and the NIA-funded ADRC network

Collections

Clinical Trial

Metadata

DDI/XML JSON

Created on

Jul 02, 2026

Last modified

Jul 07, 2026

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11412

Variable Groups

Variable group: B9 Clinician Judgment Of Symptoms

Variables 82

alcuse

12r1a. Alcohol use

b9_clinician_judgment_of_sy
mptoms_complete

beaggrs

12k. Aggression - Does the participant shout angrily, slam doors, attempt to hit or hurt others, or exhibit other verbally or physically aggressive behaviors?

beagit

12f. Agitation - Is the participant easily distressed or angered, or hard to handle, or uncooperative, or resistive to care or to help from others?

beahall

12i. Psychosis - Auditory hallucinations

beahcomp

12i2. IF YES, do the auditory hallucinations include complex sounds like voices speaking words, or music?

beahsimp

12i1. IF YES, do the auditory hallucinations include simple sounds like knocks or other simple sounds?

beanger

12q. Explosive anger - Does the participant have a "short fuse"? Do they display explosive outbursts of anger or rage?

beanx

12c. Anxiety - Does the participant seem very nervous, worried, or frightened for no apparent reason? Do they seem very tense or fidgety? Do they seem afraid to be apart from caregivers or from others that they trust?

beapathy

12a. Apathy/withdrawal - Has the participant lost interest in the world around them, lost interest in doing things, or lack motivation for starting new activities?

bedel

12j. Delusions - Does the participant have fixed, idiosyncratic beliefs that are not true? For example, insisting that others are trying to harm them or steal from them? Have they said that family members or staff are not who they say they are, or that th

bedep

12b. Depressed mood - Does the participant seem sad or depressed, or say that they feel sad or depressed?

bedisin

12m. Disinhibition - Does the participant act impulsively without thinking, say things that are not usually done or said in public, or do things that are embarrassing to caregivers or others, or do they talk personally to strangers or have disregard for p

beempath

12o. Loss of empathy - Does the participant fail to take others' feelings into account?

beeuph

12d. Euphoria - Does the participant seem too cheerful or too happy for no reason, manifest a persistent and abnormally good mood, or find humor where others do not?

behage

12g. If any of the mood-related behavioral changes in 12a-12f are present, at what age did they begin? (The clinician must use their best judgment to estimate an age of onset. If multiple symptoms [loc_wdiffage:hideunderscore] are identified, denote the a

beirrit

12e. Irritability - Does the participant get irritated and easily disturbed? Are their moods very interchangeable? Are they abnormally impatient?

bemode

13. Overall mode of onset for behavioral symptoms {loc_bemode_lastvis}

bemodex

13a. Other mode of onset - specify

beobcom

12p. Obsessions and/or compulsions - Does the participant repeatedly and excessively focus on particular ideas or activities, or have they developed new habits, like physical behaviors or stereotypical verbal phrases?

beothr

12u. Participant currently manifests meaningful change in behavior? Other:

beothrx

12u1. Participant currently manifests meaningful change in behavior - Specify other:

beperch

12n. Personality change - Does the participant exhibit bizarre behavior or behavior uncharacteristic of the participant, such as unusual collecting, suspiciousness (without delusions), unusual dress, or unusual eating behaviors?

berem

12t. REM sleep behavior disorder - While sleeping, does the participant appear to repeatedly act out their dreams (e.g., punch or flail their arms, shout, or scream)?

beremago

12t1. IF YES, at what age did the dream enactment behavior begin?

beremconf

12t2. Was REM sleep behavior disorder confirmed by polysomnography?

besubab

12r. Substance use - Does the participant currently show evidence of excessive consumption of recreational, psychoactive, or typically abused substances (substantial increase compared with prior habits, and beyond medical necessity if prescribed substance

bevhall

12h. Psychosis - Visual hallucinations

bevpatt

12h1. IF YES, do their hallucinations include patterns that are not definite objects, such as pixelation of flat uniform surfaces?

bevwell

12h2. IF YES, do their hallucinations include well formed and detailed images of objects or people, either as independent images or as part of other objects?

cannabuse

12r1e. Cannabis use

cocaineuse

12r1d. Cocaine use

cogage

9i. If any of the cognitive symptoms in 9a-9h are present, at what age did they begin? (The clinician must use their best judgment to estimate an age of onset.)

cogattn

9f. Attention/concentration - Does the participant have a short attention span or limited ability to concentrate? Are they easily distracted?

cogfluc

9g. Fluctuating cognition - Does the participant exhibit pronounced variation in attention and alertness, noticeably over hours or days-for example, long lapses or periods of staring into space, or times when their ideas have a disorganized flow?

cogjudg

9c. Executive function (judgment, planning, and problem-solving) - Does the participant have trouble planning complex activities like trips, financial transactions, parties, or group meetings?

coglang

9d. Language - Does the participant have hesitant speech, have trouble finding words, use inappropriate words without self-correction, or have trouble with speech comprehension?

cogmem

9a. Memory - Does the participant forget conversations or dates, repeat questions or statements, or misplace things more than usual?

cogmode

10. Mode of onset of cognitive symptoms Indicate the mode of onset for the most prominent cognitive problem that is causing the participant's complaints and/or affecting the participant's function.

cogmodex

10a. Specify other mode of onset of cognitive symptoms

cogori

9b. Orientation - Does the participant have trouble knowing the day, month, and year, forget names of people they know well, get lost in familiar locations, or not recognize familiar locations?

cogothr

9h. Indicate whether the participant currently is meaningfully impaired in other cognitive domains

cogothrx

9h1. Specify other cognitive domains

cogvis

9e. Visuospatial function - Does the participant have difficulty interpreting visual stimuli or finding their way around in familiar environments?

course

19. Overall course of decline of cognitive/behavioral/motor syndrome:

decclbe

11. Based on the clinician's judgment, does the participant manifest clinically meaningful neuropsychiatric symptoms or meaningful change in behavior?

decclcog

8. Based on the clinician's judgment, is the participant currently experiencing meaningful impairment in cognition?

decclin

7. Does the participant have any neuropsychiatric/behavioral symptoms, decline in any cognitive domains, or changes in any motor domains?

decclmot

14. Based on the clinician's judgment, is the participant currently experiencing any meaningful changes in motor function?

deccog

1. Does the participant report a decline in any cognitive domain (relative to stable baseline prior to onset of current syndrome)?

deccogin

4. Does the co-participant report a decline in any cognitive domain (relative to stable baseline prior to onset of current syndrome)?

decmot

2. Does the participant report a change in any motor domain (relative to stable baseline prior to onset of current syndrome )?

decmotin

5. Does the co-participant report a change in any motor domain (relative to stable baseline prior to onset of current syndrome)?

frmdateb9

0a. B9 Clinical Judgement of Symptoms - Form date

frstchg

20. Indicate the predominant domain that was first recognized as changed in the participant:

initialsb9

0b. B9 Clinical Judgement of Symptoms - Examiner's initials

langb9

0c. B9 Clinical Judgement of Symptoms - Language

loc_subuse

12r1. Record substance(s) involved:

loc_wdiffage

Clause for ' with different ages '

modeb9

0d. B9 Clinical Judgement of Symptoms - In-person or remote?

moface

15f. Change in facial expression - Has the participant's facial expression changed or become more "wooden," or masked and unexpressive?

mofalls

15b. Falls - Has the participant had an increase in frequency of falls compared with their stable baseline prior to the current syndrome?

mogait

15a. Gait disorder - Has the participant's walking changed, not specifically due to arthritis, injury, or peripheral neuropathy? Are they unsteady, or do they shuffle when walking, have little or no arm-swing, or drag a foot?

molimb

15e. Limb weakness - Has the participant noticed a change (abrupt or gradual) in limb function such that an arm and/or leg is weak compared to their prior baseline?

momoals

18. Were changes in motor function suggestive of amyotrophic lateral sclerosis (ALS) (e.g., changes in muscle strength, or muscle twitches in one or more limbs, or slurred speech)?

momode

16. Mode of onset for motor symptoms: Indicate the mode of onset for the most prominent motor problem that is causing the participant's complaints and/or affecting the participant's function.

momodex

16a. Indicate mode of onset for the most prominent motor problem that is causing the participant's complains and or affecting the participant's function - Specify other

momopark

17. Were changes in motor function suggestive of parkinsonism?

moslow

15c. Slowness - Has the participant noticeably slowed down in walking, moving, or writing by hand, other than due to an injury or illness?

mospeech

15g. Change in speech - Has the participant noted a change in speech (abrupt or gradual) such that speech is slurred, or the ability to articulate the tongue and lips to form words and sentences has declined compared to their baseline?

motorage

15h. If changes in motor function are present in 15a-15g, at what age did they begin? (The clinician must use their best judgment to estimate an age of onset. If multiple symptoms [loc_wdiffage:hideunderscore] are identified, denote the age of the earlie

motrem

15d. Tremors - Has the participant had rhythmic shaking, especially in the hands, arms, legs, head, mouth, or tongue?

opiateuse

12r1c. Opiate use

othsubuse

12r1f. Other substance use

othsubusex

12r1f1. Specify other substance use

perchage

12s. If any of the personality-related behavioral changes in 12m-12r are present, at what age did they begin? (The clinician must use their best judgment to estimate an age of onset. If multiple symptoms [loc_wdiffage:hideunderscore] are identified, denot

psychage

12l. If any of the psychosis and impulse control-related behavioral symptoms in Q12h-Q12k are present, at what age did they begin? (The clinician must use their best judgment to estimate an age of onset. If multiple symptoms [loc_wdiffage:hideunderscore]

psychsym

3. Does the participant report the development of any significant neuropsychiatric/behavioral symptoms (relative to stable baseline prior to onset of current syndrome)?

psychsymin

6. Does the co-participant report the development of any significant neuropsychiatric/behavioral symptoms (relative to stable baseline prior to onset of current syndrome)?

rmmodeb9

0d1a. What modality was used to collect this remote 'B9 Clinical Judgement of Symptoms' form?

rmreasb9

0d1. If 'B9 Clinical Judgement of Symptoms' form was completed remotely, specify reason

seduse

12r1b. Sedative/hypnotic use

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