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Uniform Data Set version 4
UDSv4 - Template

United States
Reference ID
USDv4
Producer(s)
National Alzheimer’s Coordinating Center (NACC) and the NIA-funded ADRC network
Collections
Clinical Trial
Metadata
DDI/XML JSON
Created on
Jul 02, 2026
Last modified
Jul 07, 2026
Page views
11398
  • Identification
  • Scope
  • Producers and sponsors
  • Sampling
  • Survey instrument
  • Data collection
  • Metadata production

    • Identification

    Survey ID number

    USDv4
    Title

    Uniform Data Set version 4

    Subtitle

    UDSv4 - Template
    Country
    Name Country code
    United States USA
    Abstract

    The NACC Uniform Data Set version 4 (UDSv4) is a standardized longitudinal clinical research dataset used by Alzheimer’s Disease Research Centers to collect annual participant-level information on cognition, diagnosis, medical history, function, behavior, and demographics. Introduced in 2025, UDSv4 reflects current scientific and operational needs in AD/ADRD research by adding new forms and updated measures, including social determinants of health, disease-modifying treatments, improved demographic items, Spanish-language materials, and enhanced electronic data capture. The system is designed to support harmonized multi-center research, improve data quality and accessibility, and facilitate downstream analysis through modern submission, validation, and search tools

    Scope

    Notes

    The Uniform Data Set version 4 (UDSv4) is NACC’s standardized, longitudinal data collection framework used across NIA-funded Alzheimer’s Disease Research Centers (ADRCs) in the United States. It captures annual clinical, cognitive, demographic, functional, and phenotypic information from participants ranging from cognitively normal individuals to people with mild cognitive impairment and dementia. Released in 2025, UDSv4 modernizes the previous UDS by updating content, improving accessibility, and expanding coverage of emerging concepts in Alzheimer’s disease and related dementias (AD/ADRD) research.

    Producers and sponsors

    Primary investigators
    Name
    National Alzheimer’s Coordinating Center (NACC) and the NIA-funded ADRC network

    Sampling

    Sampling Procedure

    Observational, longitudinal, standardized annual assessment

    Survey instrument

    Questionnaires

    Demographics, social determinants of health, family history, medications, health history, vitals, neurological exam, behavioral and functional assessments, neuropsychological batteries, and etiological/clinical diagnosis

    Data collection

    Mode of data collection
    • Observational, longitudinal, standardized annual assessment

    Metadata production

    DDI Document ID

    Project.UDSv4TemplateForXMLDistributio
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