Uniform Data Set version 4
UDSv4 - Template

United States

Reference ID

USDv4

Producer(s)

National Alzheimer’s Coordinating Center (NACC) and the NIA-funded ADRC network

Collections

Clinical Trial

Metadata

DDI/XML JSON

Created on

Jul 02, 2026

Last modified

Jul 07, 2026

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11417

Variable Groups

Variable group: A5-D2: Participant Health History/Clinician-assessed Medical Conditions

Variables 182

alcbinge

1h. In the past 12 months, how often did the participant have six or more drinks containing alcohol in one day?

alcdrinks

1g. On a day when the participant drinks alcoholic beverages, how many standard drinks does the participant typically consume? (Standard drink: 12oz of regular beer, 5oz of wine, 1.5oz of distilled spirits)

alcfreqyr

1f. In the past 12 months, how often has the participant had a drink containing alcohol?

angiocp

3a4. Carotid artery surgery or stenting?

anxiety

6d. Anxiety disorder (DSM-5-TR criteria)

apnea

5i. Sleep apnea

apneaoral

5i2. Typical use of an oral device or implanted breathing pacemaker for sleep apnea at night over the past 12 months?

arthloex

5f2b. Lower extremity affected by arthritis

arthrit

arthrosteo

5f1b. Type of arthritis: Osteoarthritis

arthrothr

5f1c. Type of arthritis: Other

arthrrheum

5f1a. Type of arthritis: Rheumatoid

arthspin

5f2c. Spine affected by arthritis

arthtypunk

5f1d. Type of arthritis: Unknown

arthtypx

5f1c1. Specify other type of arthritis

arthunk

5f2d. Region affected by arthritis unknown

arthupex

5f2a. Upper extremity affected by arthritis

b12def

5d. B12 deficiency

bcendage

IVP Q7e3./FVP Q7d3. Age at last use

bcpills

IVP Q7e./FVP Q7d. Has the participant ever taken birth control pills?

bcpillsyr

IVP Q7e1./FVP Q7d1. How many years in total?

bcstartage

IVP Q7e2./FVP Q7d2. Age at first use

bipolar

6b. Bipolar disorder (DSM-5-TR criteria)

bypassage

2e1. Age at most recent surgery

cancblood

5m2a. Primary site of cancer: Blood

cancbone

5m3d. Type of cancer treatment: Bone marrow transplant

cancbreast

5m2b. Primary site of cancer: Breast

cancchemo

5m3e. Type of cancer treatment: Chemotherapy

canccolon

5m2c. Primary site of cancer: Colon

canceractv

5m. Cancer, primary or metastatic - (Report all known diagnoses. Exclude non-melanoma skin cancer.)

cancerage

5m4. Age at most recent cancer diagnosis

cancermeta

5m1b. Type of cancer: Metastatic

cancerprim

5m1a. Type of cancer: Primary/non-metastatic

cancerunk

5m1c. Type of cancer: Unknown

canchorm

5m3f. Type of cancer treatment: Hormone therapy

cancimmuno

5m3c. Type of cancer treatment: Immunotherapy

canclung

5m2d. Primary site of cancer: Lung

cancmetbr

5m1b1. Type of metastatic cancer: Metastatic to brain

cancmetoth

5m1b2. Type of metastatic cancer: Metastatic to sites other than brain

cancother

5m2f. Primary site of cancer: Other

cancotherx

5m2f1. Specify other primary site of cancer

cancprost

5m2e. Primary site of cancer: Prostate

cancrad

5m3a. Type of cancer treatment: Radiation

cancresect

5m3b. Type of cancer treatment: Surgical resection

canctroth

5m3g. Type of cancer treatment: Other

canctrothx

5m3g1. Specify other type of cancer treatment

cannabis

1j. In the past 12 months, how often has the participant consumed cannabis (edibles, smoked, or vaporized)?

cardarrage

2b1. Age at most recent cardiac arrest

cardarrest

2b. Cardiac arrest (heart stopped) -

carotidage

3a5. Age at most recent carotid artery surgery or stenting

cbstroke

3a. Stroke -- by history, not exam (imaging is not required)

cbtia

3b. Transient ischemic attack (TIA)

covid19

5n. COVID-19 infection

covidhosp

5n1. Requiring hospitalization?

cpap

5i1. Typical use of breathing machine (e.g. CPAP) at night over the past 12 months

cvafib

2c. Atrial fibrillation

cvangio

2d. Coronary artery angioplasty / endarterectomy / stenting

cvbypass

2e. Coronary artery bypass procedure

cvchf

2g. Congestive heart failure (including pulmonary edema)

cvhvalve

2h. Heart valve replacement or repair

cvothr

2i. Other cardiovascular disease:

cvothrx

2i1. Other cardiovascular disease specified:

cvpacdef

2f. Pacemaker and/or defibrillator implantation

deprtreat

6a3. Choose if depressive order is treated or untreated.

diabage

5a3. Age at diabetes diagnosis

diabdiet

5a2e. Diabetes treated with: Diet

diabetes

diabglp1

5a2c. Diabetes treated with: GLP-1 receptor agonist

diabins

5a2a. Diabetes treated with: Insulin

diabmeds

5a2b. Diabetes treated with: Oral medications

diabrecact

5a2d. Diabetes treated with: Other non-insulin, non-GLP-1 receptor agonist injection medication

diabtype

5a1. Which type?

diabunk

5a2f. Diabetes treated with: Unknown

firsttbi

4h4. Age of first head injury that resulted in a period of feeling "dazed or confused," being unable to recall details of the injury, or loss of consciousness:

frmdatea5d2

0a. A5/D2 Participant Health History - Form date

generalanx

6d1. Generalized Anxiety Disorder

headache

4d. Chronic headaches

headimp

4g. Repetitive head impacts (e.g. from contact sports, intimate partner violence, or military duty), regardless of whether it caused symptoms.

headinjcon

4h2. After a head injury, what was the longest period that the participant was "dazed or confused" or unable to recall details of the injury?

headinjnum

4h3. Total number of head injuries in which the participant felt "dazed or confused", unable to recall details of the injury or experienced loss of consciousness?

headinjunc

4h1. After a head injury, what was the longest period of time that the participant was unconscious?

headinjury

4h. Head injury (e.g. in a vehicle accident, being hit by an object, in a fall, while playing sports or biking, in an assault, or during military service) that resulted in a period of feeling "dazed or confused," being unable to recall details of the inju

hivage

5s1. Age at HIV diagnosis

hivdiag

5s. Human Immunodeficiency Virus (HIV)

hrt

IVP Q7d./FVP Q7c. Has the participant taken female hormone replacement pills or patches (e.g. estrogen)?

hrtattack

2a. Heart attack (heart artery blockage) -

hrtattage

2a2. Age at most recent heart attack

hrtattmult

2a1. More than one heart attack?

hrtendage

IVP Q7d3./FVP Q7c3. Age at last use

hrtstrtage

IVP Q7d2./FVP Q7c2. Age at first use

hrtyears

IVP Q7d1./FVP Q7c1. Total number of years participant has taken female hormone replacement pills

hydroceph

4f. Normal-pressure hydrocephalus

hyperchage

5c1. Age at hypercholesterolemia diagnosis

hypercho

5c. Hypercholesterolemia (or taking medication for high cholesterol)

hypertage

5b1. Age at hypertension diagnosis

hyperten

5b. Hypertension (or taking medication for hypertension)

impamfoot

4g1a. American Football

impassault

4g1h. Physical assault

impboxing

4g1d. Boxing or mixed martial arts

imphockey

4g1c. Ice Hockey

impipv

4g1f. Intimate partner violence

impmilit

4g1g. Military service

impother

4g1i. Other (SPECIFY)

impotherx

4g1i1. Specify Other:

impsoccer

impsport

4g1e. Other contact sport

impyears

4g2. Indicate the total length of time in years that the participant was exposed to repeated hits to the head (e.g. playing American football for 7 years)

incontf

5h. Incontinence -- bowel (occurring at least weekly)

incontu

5g. Incontinence -- urinary (occurring at least weekly)

initialsa5d2

0b. A5/D2 Participant Health History - Examiner's initials

insomn

5k. Hyposomnia/insomnia (occurring at least weekly or requiring medication)

kidney

5p. Chronic kidney disease

kidneyage

5p1. Age at diagnosis

langa5d2

0c. A5/D2 Participant Health History - Language

lasttbi

4h5. Age of most recent head injury that resulted in a period of feeling "dazed or confused," being unable to recall details of the injury, or loss of consciousness:

liver

5q. Liver disease

liverage

5q1. Age at liver disease diagnosis

loc_5m1b

5m1b. Type of metastatic cancer: (Select all that apply)

loc_arth

5f1. Type of arthritis (Select all that apply)

loc_arthr

5f2. Region affected by arthritis. (Select all that apply)

loc_canc

5m1. Type of cancer (select all that apply)

loc_canctr

5m3. Type of cancer treatment (Select all that apply)

loc_cans

5m2. Primary site of cancer

loc_diab

5a2. Diabetes treated with (Select all that apply)

loc_imp

4g1. Indicate the source(s) of exposure for repeated hits to the head (Select all that apply)

loc_nomens

IVP Q7c./FVP Q7b. If the participant has stopped having menstrual periods: Indicate the reason. (Select all that apply)

majordep

6a1. Major depressive disorder (DSM-5-TR criteria*)

menarche

7a. How old was the participant when they had their first menstrual period?

modea5d2

0d. A5/D2 Participant Health History - In-person or remote?

ms

4e. Multiple Sclerosis

nomensage

IVP Q7b./FVP Q7a. How old was the participant when they had their last menstrual period?

nomenschem

IVP 7c4./FVP 7b4. Participant has stopped having menstrual periods due to chemotherapy for cancer or another condition

nomensestr

IVP 7c7./FVP 7b7. Participant has stopped having menstrual periods due to Anti-estrogen medication such as Tamoxifen, anostrozole (Arimidex). exemestane (Aromasin), or letrozole (Femara)

nomenshorm

IVP 7c6./FVP 7b6. Participant has stopped having menstrual periods due to hormonal supplements (e.g. the Pill, injections, Mirena, HRT)

nomenshyst

IVP 7c2./FVP 7b2. Participant has stopped having menstrual periods due to hysterectomy (surgical removal of uterus)

nomensnat

IVP 7c1./FVP 7b1. Participant has stopped having menstrual periods due to natural menopause

nomensoth

7c9./FVP 7b9. Other reason participant has stopped having menstrual periods

nomensothx

7c9a. Specify other reason participant has stopped having menstrual periods

nomensrad

IVP 7c5./FVP 7b5. Participant has stopped having menstrual periods due to radiation treatment or other damage/injury to reproductive organs

nomenssurg

IVP 7c3./FVP 7b3. Participant has stopped having menstrual periods due to surgical removal of both ovaries

nomensunk

IVP 7c8./FVP 7b8. Unsure of reason participant has stopped having menstrual periods

npsydev

6f. Developmental neuropsychiatric disorders (e.g., autism spectrum disorder [ASD], attention-deficit hyperactivity disorder [ADHD], dyslexia)

ocd

6d3. Obsessive-compulsive disorder (OCD)

othanxdis

6d4. Other anxiety disorder

othanxdisx

6d4a. Specify other anxiety disorder

othcondx

5t1. Specify other medical conditions or procedures

othercond

5t. Other medical conditions or procedures

otherdep

6a2. Other specified depressive disorder (DSM-5-TR criteria*)

othsleep

5l. Other sleep disorder

othsleex

5l1. Specify other sleep disorder

pacdefage

2f1. Age at first implantation

packsper

1c. Average number of packs smoked per day

panicdis

6d2. Panic Disorder

pd

4a. Parkinson's disease (PD)

pdage

4a1. Age at estimated PD symptom onset

pdothr

4b. Other parkinsonism disorder (e.g., DLB)

pdothrage

4b1. Age at parkinsonism disorder diagnosis

psycdis

6g. Other psychiatric disorders

psycdisx

6g1. Specify other psychiatric disorders

ptsd

6e. Post-traumatic stress disorder (PTSD) (DSM-5-TR criteria)

pulmonary

5o. Asthma/COPD/pulmonary disease

pvd

5r. Peripheral vascular disease

pvdage

5r1. Age at diagnosis

quitsmok

1e. If the participant quit smoking, specify the age at which he/she last smoked (i.e., quit)

rbd

5j. REM sleep behavior disorder (RBD)

rmmodea5d2

0d1a. What modality was used to collect this remote 'A5/D2 Participant Health History' form?

rmreasa5d2

0d1. If 'A5/D2 Participant Health History' form was completed remotely, specify reason

schiz

6c. Schizophrenia or other psychosis disorder (DSM-5-TR criteria)

seizage

4c2. Age at first seizure (excluding childhood febrile seizures)

seiznum

4c1. How many seizures has the participant had in the past 12 months?

seizures

4c. Epilepsy and/or history of seizures (excluding childhood febrile seizures) -

smokyrs

1b. Total years smoked

strokage

3a2. Age at most recent stroke:

strokmul

3a1. More than one stroke?

strokstat

3a3. What is status of stroke symptoms?

substpast

1i2. Prior to 12 months ago

substyear

1i1. Within the past 12 months

thyroid

5e. Thyroid disease

tiaage

3b1. Age at most recent TIA

tobac100

1a. Has participant smoked more than 100 cigarettes in their life

tobac30

1d. Has the participant smoked within the last 30 days?

valveage

2h1. Age at most recent procedure

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